BRAND: Sun Pharmaceuticals
SUBSTANCE: HCG
PACK: 5000 iu vial
The main reason for the athletes’ interest in human chorionic gonadotropin is that exogenous hCG has almost the same qualities as the luteinizing hormone of the pituitary gland. In men, luteinizing hormone stimulates germ cells in the testicles and enhances the production of androgen hormones (testosterone). Therefore, injection Pregnil is used by athletes for increased production of testosterone. Human chorionic gonadotropin is used most often in combination with anabolic steroids (at the end or in the middle of the steroid cycle). As already mentioned, anabolic steroids, on the principle of feedback inhibit the production of follicle-stimulating and luteinizing hormones, as a result of which the production of testosterone decreases. Since the body normally needs time to normalize the testosterone production process, an extremely difficult transition phase occurs for the athlete after stopping the steroid drug, which often passes with a significant loss of strength and mass. As the end of the steroid course, taking a human chorionic gonadotropin helps to return the testes to their original state, including their magnitude. Temporary injections of human chorionic gonadotropin during the intake of anabolic steroids can prevent testicular atrophy, so many athletes take Pregnil in the middle of the steroid cycle for 2-3 weeks. It is noticed that just at this time the athlete achieves his best success in relation to mass and strength. This is explained by the fact that, on the one hand, the athlete has a high level of his own testosterone due to the use of hCG, and on the other – there is a high concentration of anabolic agents in the blood due to the use of steroids.
Pharmachologic effect
The active substance of rotting is human chorionic gonadotropin, which is obtained from the urine of pregnant women. Pregnil stimulates the formation of steroid hormones in the sex glands due to the effect of human luteinizing hormone (LH). In females, the drug causes an increase in the synthesis of progesterone and estrogens after ovulation; in male patients, pregnil stimulates the synthesis of testosterone. The appearance of antibodies against human chorionic gonadotropin in the body was not observed with the introduction of pregnil.
The maximum concentration of human chorionic gonadotropin (hCG) in blood plasma in women is determined in 20 hours, in men – after 6 hours (after injection intramuscularly once). Significant differences in pharmacokinetics in men and women are mainly due to the greater thickness of subcutaneous fat in women in the buttock area. After intramuscular injection, hCG is absorbed into the blood well. The half-life of the decay is 33 hours. Approximately 80% of the drug is destroyed in the kidney tissue. Elimination – with urine.
Side effects
Rarely – skin rash; In men, sodium and water retention (when taking high doses). After treatment, there is an increased risk of miscarriage or the development of multiple pregnancies.
