BRAND: RPG

SUBSTANCE: Aldactone (Spironolactone)

PACK: 25mg 30 pills

Pharmachologic effect

Potassium, magnesium-saving diuretic. It is a competitive antagonist of aldosterone on the effect on the distal sections of the nephron (competes for binding sites on cytoplasmic protein receptors, reduces the synthesis of permeases in the aldosterone-dependent region of the collecting tubules and distal tubules), increases the excretion of Na +, Cl- and water and reduces the excretion of K + and urea, Reduces the titratable acidity of urine. Strengthening diuresis causes a hypotensive effect, which is unstable. The hypotensive effect does not depend on the level of renin in the blood plasma and does not appear with normal blood pressure.

Side effects:

Nausea, vomiting, abdominal pain, gastritis, ulceration and bleeding in the digestive tract, intestinal colic, diarrhea or constipation, dizziness; Drowsiness, lethargy, headache, inhibition, ataxia, muscle spasms, decreased potency, increased urea concentration, hypercreatininaemia, hyperuricemia, water-salt metabolism and CBS (metabolic hypochloraemic acidosis or alkalosis); Megaloblasticosis, agranulocytosis, thrombocytopenia.

Precautionary measures

During treatment should avoid excessive intake of potassium in the body. It is not recommended to combine with other potassium-sparing diuretics. At simultaneous appointment with hypotensive and diuretic means it is necessary to reduce doses.